活血、补气中药抗肾缺血再灌注损伤作用机制研究进展

摘要

本文就近10年来活血、补气中药抗肾缺血再灌注损伤作用机制的研究进展进行了综述.活血、补气中药对肾缺血再灌注损伤具有一定的保护作用,其作用机制包括对炎症反应、氧自由基及Ca2+超载、一氧化氮和细胞凋亡等的影响.其具体机制可能包括:(1)抑制肾组织中细胞间粘附分子-1(ICAM-1)表达,减少血清中肿瘤坏死因子(TNF-α)的含量;(2)抑制肾缺血再灌注时脂质过氧化的升高,增加氧自由基清除;(3)抑制NF-κB的表达、降低诱生型一氧化氮合成酶(iNOS)活性;(4)影响Bcl-2/Bax表达,抑制细胞凋亡等.%TCM for invigorating blood and enriching qi have certain protective effect against renal ischemia-reperfusion injuiry, its mechanism includes the effect on inflammatory cascade, oxigen free radical and Calcium overloading, nitric oxide and cell apotosis,This article summarizes the development of studies on the mechanism of TCM for promoting blood flowing and invigorating vital energy against renal ischemical reperfusion injury in the recent ten years. The mechanism may includes:(1)inhibiting the expression of ICAM-1 in nephridial issue;(2)inhibiting lipid peroxidation increase and increasing the elimination of oxygen radical while renal ischemical reperfusion happens ;(3)inhibiting the expression of NF-kB and reducing the activity of iNOS ;(4)Effecting the expression of Bcl-2/Bax and inhibiting cell apoptosis.