Objective To explore the influence of extreme climate variations on golden hamster's immunity functions based on correspondence between nature and human theory. Methods Manual simulation climate was adopted to simulate six types of climates. When corresponding intervention was finished,blood samples were collected after 24 hours and 72 hours respectively. MT、IgG and IgM of serum was detected. Results (1) During the experiment,death rate was 36% of GWGS group while that was 0 of other groups. (2) Spleen index has no significant change during 72 hours after the extreme climate change. (3)24 hours after the extreme climate change,thymus index of most samples from ZS group,ZJ group and GWGS group was significantly different from that of ZC group(P<0. 05). 72 hours later after the extreme climate change,the difference gets more obvious(P<0. 01). (4) MT、IgG and IgM level of serum was sig-nificantly increased of 72 hours later after the sudden temperature drop and continuous low temperature. (5)The change law of MT、IgG and IgM level was increased(24h) before decreasing(72h) in GWGS and CWGS groups, the results all showed the remarkable difference compared with the ZC group 72 hours later after the extreme climate change. Conclusions (1) Damp-heat influencesimmunity system was more sig-nificantly than single pathogenic factor. ( 2 ) Thymus index is more sensitive to the change of extreme climate. (3) MT、IgG and IgMof serum is induced different types of immune responses by low or high tem-peratures and the influence is hysteresis nature.%目的：基于中医“天人相应”理论，部分揭示气候突变对正常机体免疫功能的影响。方法借助人工模拟系统，进行不同气候条件模拟。在干预后24小时、72小时取血，测定血清褪黑素、免疫球蛋白G、免疫球蛋白M等相关指标。结果(1)除高温高湿组动物出现死亡外(死亡率高达36%)，其他各组动物死亡数为0。(2)人工模拟的六种极端气候干预后，脾脏指数未发生明显变化。(3)在气温骤升、气温骤降和常温高湿条件干预24小时后，胸腺指数有所升高，出现显著性差异(P<0.05)，气温骤变干预后72小时差异更加明显(P<0.01)。(4)气温骤降后72小时及持续低温时，褪黑素、免疫球蛋白M、免疫球蛋白G出现明显升高。(5)高温高湿和常温高湿干预后褪黑素、免疫球蛋白G和免疫球蛋白M出现了先升高(24小时)后降低(72小时)，在72小时时与正常气候组相比有显著性差异。结论(1)湿热邪气相合侵袭人体，对机体免疫力的影响要高于单独的某一种邪气。(2)与脾脏指数比较而言，胸腺指数对极端气候的变化更为敏感。(3)血清褪黑素、免疫球蛋白G和免疫球蛋白M在高温、低温刺激时呈现出的应答反应不同，但都有一定的滞后效应。
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