首页>
外文期刊>基因组蛋白质组与生物信息学报(英文版)
>Molecular Phylogenetics and Functional Evolution of Major RNA Recognition Domains of Recently Cloned and Characterized Autoimmune RNA-Binding Particle
【24h】
Molecular Phylogenetics and Functional Evolution of Major RNA Recognition Domains of Recently Cloned and Characterized Autoimmune RNA-Binding Particle
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are spliceosomal macromolecular assemblages and thus actively participate in pre-mRNA metabolism. They are composed of evolutionarily conserved and tandemly repeated motifs, where both RNA-binding and protein-protein recognition occur to achieve cellular activities. By yet unknown mechanisms, these ribonucleoprotein (RNP) particles are targeted by autoantibodies and hence play significant role in a variety of human systemic autoimmune diseases. This feature makes them important prognostic markers in terms of molecular epidemiology and pathogenesis of autoimmunity.Since RNP domain is one of the most conserved and widespread scaffolds, evolutiona lyses of these RNA-binding domains can provide further clues on disease-specific epitope formation. The study presented herein represents a sequence comparison of RNA-recognition regions of recently cloned and characterized human hnRNP A3 with those of other relevant hnRNP A/B-type proteins.Their implications in human autoimmunity are particularly emphasized.
展开▼
机译:异质核核糖核蛋白(hnRNPs)是剪接体大分子组合,因此可以积极参与mRNA之前的代谢。它们由进化保守的和串联重复的基元组成,其中RNA结合和蛋白质-蛋白质识别均发生以实现细胞活性。通过未知的机制,这些核糖核蛋白(RNP)颗粒被自身抗体靶向,因此在多种人类系统性自身免疫疾病中起着重要作用。该特征使它们成为分子流行病学和自身免疫性发病机制的重要预后标志物。由于RNP结构域是最保守和分布最广泛的支架之一,因此这些RNA结合结构域的进化分析可以为疾病特异性表位的形成提供进一步的线索。本文介绍的研究代表了最近克隆并表征的人hnRNP A3与其他相关hnRNP A / B型蛋白的RNA识别区域的序列比较,特别强调了它们对人自身免疫的影响。
展开▼