过敏性咳嗽患儿食物不耐受抗体及血清细胞因子水平分析

摘要

Objective:To observe antibody immunoglobulin (IgG) and serum levels of cytokine of allergic cough children.Methods:85 children with allergic cough children and 60 healthy children were chosen in this study.ELISA method was employed to detect food-specif⁃ic IgG antibodies for 14 food allergens and serum levels of interleukin(IL)-4,transforming growth factor(TGF)-β,tumor necrosis factor(TNF)-α, and Interferon(IFN)-γ. Results:Food-specific IgG antibodies was 70 cases with positive rate of 82.35%,which was higher than control group with 28.33%with statistical significance(χ2=42.77,P<0.05).Serum levels of IL-4,TGF-β,TNF-α,and IFN-γin allergic cough children with positive IgG were obviously higher than control group and allergic cough children with negative IgG(P<0.05).Conclusion:Food intolerance IgG and serum levels of cytokine of are significantly abnormal in allergic cough children,which would provide evidences for diagnosis and treatment and prevention of allergic cough children.%目的：观察过敏性咳嗽患儿食物不耐受抗体IgG水平及血清细胞因子水平。方法：选取2013年10月至2015年6月我院收治的85例过敏性咳嗽患儿和60例健康体检儿童为研究对象。酶联免疫吸附法（ELISA）检测两组血清中14种食物过敏原特异性IgG抗体和血清白细胞介素（IL）-4、转化生长因子（TGF）-β、肿瘤坏死因子（TNF）-α和干扰素（IFN）-γ水平。结果：过敏性咳嗽患儿出现食物特异性IgG抗体者70例（阳性率为82.35％），对照组为17例（阳性率为28.33％），比较差异有统计学意义（χ2=42.77， P＜0.05）。过敏性咳嗽IgG阳性患儿血清炎性因子IL-4、TGF-β、TNF-α及IFN-γ水平均高于对照组和过敏性咳嗽IgG阴性患儿（P＜0.05）。结论：过敏性咳嗽患儿食物不耐受IgG抗体及血清细胞因子水平明显异常，为该病的诊疗和预防提供依据。