超声生物显微镜(ultrasound biomicroscopy,UBM)作为近年新兴的活体成像技术,已成功用于观察各种小动物模型及人类浅表组织.在心血管疾病研究领域,该技术显现出独特优势,如非侵入性、观察连续性、高分辨率、实时性、价格优势等,使充分利用模型动物进行实时连续心血管形态功能分析成为可能.本文对UBM的特点进行介绍,并就其在动脉粥样斑块、心肌梗死、心力衰竭、心肌病、瓣膜病、心脏发育和引导穿刺等方面的应用进行综述.%Ultrasound biomicroscopy (UBM) is an innovative technique of living tissues imaging,which has been used in visualization of small-animal models and superficial human tissues. When applying in cardiovascular researches, its unique advantages, such as noninvasive, quick and real-time imaging, high-resolution and low cost, increase the possibility of obtaining the structural, functional,and hemodynamic information consecutively from animal models substantially. This review describes the characters of ultrasound biomicroscopy and highlights its current medical applications in atherosclerosis,myocardial infarction, heart failure, cardiomyopathy, valve disease, embryonic heart development and ultrasound guided injection.
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