高密度脂蛋白(HDL)抗动脉粥样硬化研究进展

摘要

It is well known that anti-atherogenic actions of high-density lipoprotein ( HDL) are thought to be reverse cholesterol transport through its associated apolipoprotein A-I (ApoA-I). Recently mounting evidence indicates that multiple anti-atherogenic or anti-inflammatory actions of HDL independent of cholesterol metabolism are mediated by HDL-associated sphingosine 1-phosphate (S1P) through S1P receptors and by ApoA-I through scavenger receptor class BI (SR-BI).%血浆高密度脂蛋白(high-density lipoprotein,HDL)通过其载脂蛋白A-I(apolipoprotein A-I,ApoA-I)介导胆固醇逆向转运,呈现抗动脉粥样硬化(atherosclerosis,AS)功能.近来大量研究结果显示高密度脂蛋白的多种抗AS、抗炎功能与胆固醇代谢无关,而是由其联结的鞘氨醇-1-磷酸(sphingosine 1-phosphate,S1P)和ApoA-I分别通过S1P受体和清道夫受体B-I(scavenger receptor class BI,SR-BI)介导的细胞内信号通路来实现.