建立鳗鱼肉中8种奎诺酮残留量的平行定量浓缩仪-超高效液相色谱-串联质谱检测方法。以氘代试剂为内标,样品经酸化乙腈萃取后,平行定量浓缩仪浓缩,用正己烷脱脂,采用超高效液相色谱-串联质谱选择反应监测正离子模式测定,可同时对鱼肉中奎诺酮进行定性和定量。奎诺酮检出限可达0.5μg/kg,定量低限可达1.0μg/kg。在2.5～200ng/mL范围内峰强度与质量浓度的线性关系良好（r〉0.99）。方法的平均回收率在81.4%～111.1%之间。方法简单、快速、稳定、准确、灵敏度高,适合于实验室大批量检测水产品样品。%A method for the simultaneous determination of eight quinolone residues in eel was developed by syncore analyst- ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry （SA-UPLC-MS/MS）. Deuterium substituted reagents were added as internal standards before sample extraction with acidified acetonitrile, followed by concen- tration using a Syncore Analyst and clean-up with hexane. Eight quinolone residues were analyzed by UPLC-MS/MS under positive ion mode. The limit of detection of the method for eight quinolones was 0.5 ta g/kg, and the limit of quantification was 1.0 lag/kg. The calibration curves showed good linearity over the concentration range of 2.5-200 ng/mL （r 〉 0.99）. The average recovery rates were 81.4% - 11.1% across three spike levels （n = 6）. This method was simple, rapid, stable, reliable, sensitive and suitable for the determination of bulk aquatic products.
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