大蒜提取物对铜绿假单胞菌生物膜形成的影响

摘要

The effect of garlic extract on the development of biofilm in Pseudomonas aeruginosa PAO1 was studied.The biofilm production and factors correlated with the biofilm formation in PAO1 were evaluated.The results showed that the garlic extract not only inhibited the development of biofilm,extracellular polysaccharide production,and motility characteristic,but also had synergistic effect with Azithromycin when the concentration of garlic extractdidn't affect growth of PAO1.The results suggested that garlic extract could inhibit the development of biofilm and reduce the expression of factors correlated with the biofilm formation in P.aeruginosa PAO1 by interfering with their QS systems.%研究了大蒜提取物对铜绿假单胞菌PAO1生物膜形成的影响.通过对铜绿假单胞菌PA01生物膜以及与生物膜形成相关因素的测定,结果表明大蒜提取物在不影响PAO1生长的浓度条件下,能抑制其生物膜的形成、胞外多糖的产生以及浮游现象;与阿奇霉素具有协同作用.因此,大蒜提取物通过干扰铜绿假单胞菌PAO1群体感应系统来抑制其生物膜的形成,降低与生物膜形成相关特性的表达.