口服透明质酸对皮肤水分的改善作用及体内抗氧化作用研究

摘要

Objective To study the effect of oral hyaluronan on skin moisture and its antioxidation functionin vivo, as well as its safety.Methods In this double-blind clinical study, the subjects were divided into trial group and control group, respectively. The skin moisture and serum MDA, SOD, GSH-Px levels and other biochemical indices were analyzed before and after test. Results Skin moisture of the hyaluronan treated group after test increased significantly compared with that before test and the placebo treated group (P<0.05). Serum SOD in trial group increased significantly after test (P<0.05). The safety indices of the subjects were within the normal range in the hyaluronan treated groups.Conclusion Oral hyaluronan can improve the skin moisture, and has high antioxidant activity and high safetyin vivo.%目的：考察口服透明质酸（HA）对皮肤水分的改善作用、体内抗氧化作用及安全性。方法按双盲法进行人体试食试验，分为试食组与对照组，分析两组受试者皮肤水分及血清中丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）的含量变化，并对受试者身体情况和各生化指标进行安全性考察。结果试食组的皮肤水分明显提高，与试食前和对照组比较，差异均有统计学意义（P<0.05）；试食组血清SOD活性与对照组试食后及自身试验前比较，差异均有统计学意义（P<0.05）；受试者安全性指标均在正常范围内。结论口服HA可改善人体皮肤水分，具有体内抗氧化作用，且口服安全性高。