雷帕霉素在肿瘤治疗方面研究进展

摘要

雷帕霉素(RAPA)在肿瘤治疗方面的研究及应用日益增多,单独应用或联合用药在体外、体内均表现显著的抗肿瘤效果.RAPA通过抑制哺乳动物雷帕霉素靶蛋白(mTOR)受体,影响其转导的多种信号通路,从而发挥抗血管生成、阻滞细胞周期和促进细胞凋亡等多种作用,对肿瘤的增殖、侵袭和转移等过程产生影响.本文综述RAPA在不同肿瘤治疗方面的研究进展,为其在生物医药领域进一步应用提供新方法和新思路.%Recently, rapamycin is increasingly studied and utilized in anti-cancer therapy. Rapamycin alone or combined with other antineoplastic shows significant antitumor effects in vitro and in vivo. Rapamycin produces the effects in anti-angiogenesis, blocking cell cycle, promoting cell apoptosis and so on, by inhibiting mTOR receptors to influence multiple signal transduction pathways. Those signal pathways can interfere with the transcription of various factors which can regulate proliferation, invasion and metastasis of tumors. This review summarizes the progress in rapamycin for the treatment of different tumors, and provides new methods and new ideas for its further application in the field of biomedicine.