艾司西酞普兰与舍曲林治疗中国老年抑郁症患者的系统评价

摘要

OBJECTIVE: To evaluate the efficacy and safety of escitalopram versus sertrline in treatment of Chinese senile patients with depression. METHODS:The data of 9 randomized controlled trials comparing escitalopram and sertraline in treatment of senile patients with depression retrieved from domestic journal between 1994 and 2013 were subjected to a quantitative meta⁃analysis. RESULTS: There was no significant difference in clinical efficacy between escitalopram and sertraline(P>0�05,OR=1�37,95%CI=0�80⁃2�34). The incidence rates of nausea, sweating and tachycardia in sertraline group were significantly higher than in escitalopram group ( P0�05 ) . CONCLUSIONS: Escitalopram is as effective as sertraline but safer than the sertraline in treatment of Chinese senile patients with depression.%目的：评价艾司西酞普兰与舍曲林治疗中国老年抑郁症患者的疗效与安全性。方法：用计算机检索国内关于艾司西酞普兰与舍曲林治疗老年抑郁症的随机对照试验（ randomized controlled trial，RCT），应用系统评价方法对检索到的9篇RCT文献进行定量综合分析。结果：艾司西酞普兰与舍曲林的疗效差异无统计学意义（P＞0�05，OR＝1�37，95％CI＝0�80～2�34）。舍曲林组患者发生恶心、出汗、心动过速比艾司西酞普兰组多见，差异有统计学意义（P＜0�05）；2组患者其他不良反应发生率比较，差异无统计学意义（P＞0�05）。结论：艾司西酞普兰与舍曲林治疗中国老年抑郁症患者的疗效相似，但艾司西酞普兰的不良反应较舍曲林轻微。