目的：观察体外循环热灌注化疗治疗恶性胸腹水的疗效及不良反应。方法：选择恶性胸腹水患者100例，按照随机数字表法分为治疗组及对照组。治疗组患者50例，采用HGGZ-102体腔循环热化疗系统行体腔热疗，腔内温度达41～43℃，给予顺铂50 mg、地塞米松10 mg注入体腔，体腔循环持续60 min；对照组患者50例，给予体腔注入顺铂50 mg。2组患者均进行1周2次的治疗，疗程为2周。结果：治疗组患者总有效率为76�0％（38/50）；对照组为46�0％（23/50），治疗组明显优于对照组（ P＜0�05）；2组不良反应发生率相当。结论：体腔循环灌注热化疗治疗恶性胸腹水疗效好，不良反应可以耐受。%OBJECTIVE:To evaluate the efficacy and side effects of extracorporeal circulation hyperthermic perfusion chemotherapy for malignant pleural effusion or ascites. METHODS:100 cases of malignant pleural effusion or ascites were randomized to either treatment group or control group of 50 cases each. The treatment group received thermotherapy using HGGZ-102 body cavity circulating thermochemotherapy system with intra-cavity maintained at 41-43 ℃ circulation maintained for 60 min and into the cavity cisplatin ( 50 mg ) and dexamethasone ( 10 mg ) were injected;while the control group were injected with cisplatin(50 mg) via body cavity. The medications were given twice a week for two consecutive weeks. RESULTS:The response rate in the treatment group was significantly higher than in the control group [ 76�0%( 38/50 ) vs. 46�0%( 23/50 ); P <0�05 ); there was no statistically significant difference between the two groups in terms of the incidence of adverse reactions. CONCLUSIONS: Body cavity circumfusion thermochemotherapy is effective for malignant pleural effusion or ascites with tolerable adverse reactions.
展开▼
