2010-2013年云南省传染病专科医院抗菌药物使用强度分析

摘要

OBJECTIVE:OBJCTIVE:To investigate the application of antibiotics in the Infectious Disease Specialist Hospital of Yunnan Province ( hereinafter referred to as "our hospital") , and to provide evidence for the clinical application of antibiotics. METHODS:By retrospective study,the usage data of antibiotics from 2010 to 2013 were collected and the defined daily dose ( DDD ) was set as the unit, the antibacterial use density ( AUD ) was calculated by Excel 2003 then the results was analyzed. RESULTS:The AUD of our hospital was 39. 562 DDD/(100 patients·d)in 2010;in 2011, the AUD was 39. 246 DDD/(100 patients·d); in 2012, the AUD was 30. 167 DDD/(100 patients·d);in 2013, the AUD was 27. 012 DDD/(100 patients·d). The total AUD of antibiotics had been decreased yearly. Compared with other domestic hospitals, the AUD of antibiotics in our hospital was low. The top ten antibiotics ranked by AUD were antifungal drug,levofloxacin,sulfamethoxazole and the third generation cephalosporin etc. CONCLUSIONS:The tendency of antibiotics use became more reasonable, stable and concentrated yearly in our hospital,but a small amount of varieties of the AUD( carbapenems and glycopeptides) were increased yearly,and had some problems of over medication.%目的:了解云南省传染病专科医院(以下简称"我院")抗菌药物使用情况,为合理使用抗菌药物提供依据. 方法:回顾性收集2010-2013年我院抗菌药物使用数据,以限定日剂量为单位,采用Excel 2003软件计算抗菌药物使用强度( antibiotics use density, AUD)并进行分析. 结果:2010年我院AUD为39. 562 DDD/(100人·d),2011年为39. 246 DDD/(100人·d),2012年AUD为30. 167 DDD/(100人·d),2013年AUD为27. 012 DDD/(100人·d),总体值呈逐年下降趋势,与国内其他医院相比,我院AUD偏低. 2010-2013年AUD排序居前10位的抗菌药物主要为抗真菌药、左氧氟沙星、复方磺胺甲 唑、第3代头孢菌素等. 结论:我院抗菌药物的使用有逐年合理、稳定、集中的趋势,但少数品种(碳青霉烯类及糖肽类)的AUD逐年升高,可能存在过度使用情况.