阿奇霉素序贯疗法治疗儿童支原体肺炎的疗效观察Δ

摘要

目的：探讨阿奇霉素序贯疗法治疗儿童支原体肺炎的临床疗效及安全性。方法：选择2013年5月—2015年5月收治的支原体肺炎患儿160例，按随机数字表法分为观察组和对照组各80例。2组患儿均给予化痰、解痉等常规治疗，缺氧症状明显的患儿给予间断吸氧治疗。在以上治疗的基础上，观察组患儿应用阿奇霉素序贯疗法，对照组应用红霉素序贯疗法。观察2组患儿的疗效、细菌清除情况、临床症状评分变化情况、症状持续时间、住院时间、治疗费用及不良反应发生情况。结果：治疗后，观察组患儿的总有效率为96．25％（77／80），明显高于对照组的76．25％（61／80），差异有统计学意义（P＜0．05）；观察组患儿的细菌清除率明显高于对照组，差异有统计学意义（ P＜0．05）；2组患儿发热、咳嗽、肺部啰音评分均显著低于治疗前，且观察组明显低于对照组，差异有统计学意义（P＜0．05）；观察组患儿发热、咳嗽、喘息、病灶完全吸收及住院时间均明显短于对照组，差异有统计学意义（P＜0．05）；观察组患儿的不良反应发生率明显低于对照组，差异有统计学意义（P＜0．05）。结论：阿奇霉素序贯疗法治疗小儿支气管肺炎疗效好，不良反应少，值得临床推广。%OBJECTIVE:To investigate the clinic efficacy and safety of azithromycin sequential therapy in treatment of children with mycoplasma pneumonia .METHODS:160 children with mycoplasma pneumonia admitted from May 2013 to May 2015 were selected to be divided into observation group and control group via the random number table , with 80 cases in each .Two group of patients were treated with conventional treatment of phlegm of resolving, spasmolysis, etc..Children with hypoxia symptoms additionally received intermittent inhalation .Based on the above treatment , the observation group were treated with azithromycin sequential therapy , the control group received erythromycin sequential therapy .The efficacy , elimination of bacteria , changes of clinical symptom score , duration, length of stay, treatment costs, and adverse drug reactions in two groups were observed .RESULTS: The total effective rate of observation group was 96.25%(77/80), significantly higher than that of control group [76.25%(61/80)], with statistically significant difference (P<0.05).The elimination rate of bacteria in observation group were significantly higher than that of control group , with statistically significant difference ( P<0.05 ) .Compared with before treatment, the clinical symptoms as fever , cough, score of lung rale in two groups were significantly decreased after treatment , and the indicators in observation group were significantly lower than that of control group , with statistically significant difference(P<0.05).Meanwhile, time of fever, cough, wheeze, complete resolved time of lesions and length of stay in observation group were significantly lower than that of control group , with statistically significant difference(P<0.05).The incidence of adverse drug reactions of observation group was significantly lower than that of control group , with statistically significant difference ( P<0.05 ) . CONCLUSIONS: The efficacy of azithromycin sequential therapy in treatment of children with mycoplasma pneumonia is remarkable , with few adversedrug reactions.It is worthy of clinical application and promotion .