痰热清注射液联合胸腺五肽注射液治疗脑卒中并发肺部感染的疗效观察Δ

摘要

OBJECTIVE:To probe into the efficacy of Tanreqing injections combined with Thymopentin injections in treatment of stroke complicated with pulmonary infection .METHODS: 110 patients with stroke complicated with pulmonary infection admitted from Sept .2014 to Sept.2015 were selected to be divided into observation group and control group via the random number table , with 55 cases in each .The control group were treated with Tanreqing injections , while the observation group additionally received Thymopentin injections based on the control group .The efficacy , remission time of fever and cough , disappearance time of lung rales , recovery time of numeration of leukocyte and biochemical indexes of blood , length of stay , negative conversion ratio of sputum pathogenic bacteria and adverse drug reactions in two groups were observed .RESULTS: After treatment , the total effective rate of observation group was 94.55%(52/55), significantly higher than that of control group [83.64%(46/55)], with statistically significant difference ( P <0.05 ) .The remission time of fever and cough , disappearance time of lung rales , recovery time of numeration of leukocyte and biochemical indexes of blood and length of stay in observation group were shorter than that of control group , yet the negative conversion ratio of sputum pathogenic bacteria was higher than that of control group , with statistically significant difference ( P<0.05 ) .The incidence of adverse drug reactions in observation group was 5.45%( 3/55 ) , significantly lower than that of control group [ 12.73%( 7/55 ) ] , with statistically significant difference(P<0.05).And there was no obvious adverse drug reactions in two groups .CONCLUSIONS:The efficacy of Tanreqing injections combined with Thymopentin injections in treatment of stroke complicated with pulmonary infection is remarkable , with high safety , which is worthy of clinical application and promotion .%目的：探讨痰热清注射液联合胸腺五肽注射液治疗脑卒中并发肺部感染的疗效。方法：选取2014年9月—2015年9月收治的110例脑卒中并发肺部感染患者，采用随机数字表法分为对照组和观察组各55例。对照组患者给予痰热清注射液，观察组患者在对照组治疗的基础上加用胸腺五肽注射液，观察2组患者的疗效、退热时间、咳嗽缓解时间、肺部啰音消失时间、白细胞计数恢复时间、血液生化指标恢复时间、住院时间、痰病原菌培养转阴及不良反应发生情况。结果：治疗后，观察组患者总有效率为94．55％（52／55），明显高于对照组的83．64％（46／55），差异有统计学意义（P＜0．05）；观察组患者的退热时间、咳嗽缓解时间、肺部啰音消失时间、白细胞计数恢复时间、血液生化指标恢复时间及住院时间均短于对照组，且痰病原菌培养转阴率明显高于对照组，差异均有统计学意义（P＜0．05）；观察组患者不良反应发生率为5．45％（3／55），明显低于对照组的12．73％（7／55），差异有统计学意义（ P＜0．05），2组患者均未见明显不良反应。结论：痰热清注射液联合胸腺五肽注射液治疗脑卒中并发肺部感染疗效确切，可明显改善患者的临床症状，且安全性好，值得临床推广。