丙戊酸钠及氯硝西泮治疗迟发性运动障碍的疗效观察

摘要

OBJECTIVE:To probe into the efficacy and adverse reactions of sodium valproate and clonazepam in treatment of tardive dyskinesia (TD).METHODS:123 cases with TD were divided into observation group and control group via the random number table .The observation group were treated with sodium valproate and clonazepam , the control group received placebo vitamin B 6 .The effects of before and after 2, 4, 8 weeks were determined via abnormal involuntary movement scale ( AIMS ) .The efficacy and adverse reactions in patients were observed .RESULTS:After treatment with sodium valproate and clonazepam , scores of AIMS after 2, 4, 8 weeks were significantly decreased than before in observation group, which was better than the control group, with statistically significant difference (P<0.05).The effective rate of TD was 90.00%in observation group, while in control group, it was lower than 10.00%, with statistically significant difference (P<0.05).There was no obvious adverse reactions between two group pf patients .CONCLUSIONS:Sodium valproate and clonazepam in treatment of TD is safe and effective , it is worthy of clinical promotion .%目的：探讨丙戊酸钠及氯硝西泮治疗迟发性运动障碍（ tardive dyskinesia ，TD）的疗效和不良反应。方法：将123例迟发性运动障碍患者按随机数字表法分为观察组和对照组，观察组患者给予丙戊酸钠和氯硝西泮，对照组患者给予安慰剂维生素B6。通过异常不自主运动量表（ AIMS）评分对患者治疗前，治疗第2、4、8周末的效果进行评定，观察患者的疗效及不良反应。结果：观察组患者应用丙戊酸钠和氯硝西泮治疗后，第2、4、8周末AIMS评分较治疗前明显下降，且明显优于对照组，差异均有统计学意义（ P＜0.05）；观察组患者TD部位的有效率均达到90.00％以上，而对照组患者有效率均低于10.00％，差异均有统计学意义（P＜0.05）；2组患者均未见明显不良反应。结论：丙戊酸钠及氯硝西泮治疗TD安全有效，值得临床推广。