盐酸氨溴索联合地塞米松鼓室内注射治疗分泌性中耳炎的疗效观察

摘要

目的：探讨盐酸氨溴索联合地塞米松鼓室内注射治疗分泌性中耳炎的临床疗效。方法：选取2012年1月—2015年12月黄冈市中心医院收治的分泌性中耳炎患者100例（120耳）作为研究对象。以随机数字表法分为观察组和对照组各50例。对照组患者鼓膜穿刺抽液后注入地塞米松，观察组患者鼓膜穿刺抽液后注入盐酸氨溴索和地塞米松。观察2组患者的临床疗效，比较2组患者治疗前后的纯音听阈测试气导听力水平。结果：观察组患者的临床总有效率为90％（45／50），明显高于对照组的72％（36／50），差异有统计学意义（P＜0.05）。治疗后，2组患者的各频率纯音听阈测试气导听力水平均明显高于治疗前，且观察组患者各频率纯音听阈测试气导听力水平明显高于对照组，差异均有统计学意义（ P＜0.05）。结论：采用盐酸氨溴索联合地塞米松鼓室内注射治疗分泌性中耳炎，临床疗效显著，可有效改善患者的听力水平。%OBJECTIVE: To probe into the clinical efficacy of ambroxol hydrochloride combined with dexamethasone in intratympanic injection in treatment of secretory otitis media .METHODS:100 patients (120 ears) with secretory otitis media admitted into Huanggang Central Hospital from Jan .2012 to Dec.2015 were selected to be divided into observation group and control group via the random number table , with 50 cases in each.The control group were treated with tympanic membrane puncture fluid after injection of dexamethasone , while the observation group received tympanic membrane puncture fluid after injection of ambroxol hydrochloride and dexamethasone .The clinical total efficiency were observed , and pure tone audiometry air conduction hearing were compared between two groups before and after treatment .RESULTS: The clinical total efficiency of observation group was 90%( 45/50 ) , significantly higher than that of control group [ 72%( 36/50 )], with statistical significance ( P <0.05 ).After treatment, the frequency of pure tone audiometry by air conduction hearing in two groups were significantly improved than that of before treatment , and the observation group were significantly higher than the control group , with statistical significance ( P <0.05 ) . CONCLUSIONS: The clinical efficacy of ambroxol hydrochloride combined with dexamethasone in intratympanic injection in treatment of secretory otitis media is remarkable , which can effectively improve the hearing level of patients .