ObjectiveEvaluating the value of combined detection of serum markers: placental growth factor,placental protein 13,β-human choionic gonadotophin and interleukin-18 in middle and late gestation to predict pre-eclampsia.MethodsForty-eight cases that were diagnosed as pre-eclampsia were taken as case group, among which 22 patients was mild pre-eclampsia patients and 26 cases was severe pre-eclampsia patients. Forty-eight normal gravida were regarded as control group. The enlyme-linked immunosorbent assay was used to test the content of placental growth factor, placental protein 13, β-human choionic gonadotophin and interleukin-18, at the same time, the differences between groups were evaluated, so were the sensitivities and specificity of combined detection and area under the receiver operating characteristic curves.ResultsThe results of combined detection of sensitivities, specifi city and area under of receiver operating characteristic curves were higher than single detection, and the sensitivities of combined detection in mild pre-eclampsia and severe pre-elcampsia was 95.5% and 88.5% , the specifi city was 97.9% and 100%, and the area under the receiver operating characteristic curves are 0.966 and 0.948, respectively.ConclusionThe high diagnosis accuracy, sensitivities and specifi city of serum combined detection has crucial reference value for the prediction of pre-eclampsia.%目的：评价妊娠中晚期孕妇血清胎盘生长因子（PLGF）、胎盘蛋白13（PP13）、β-绒毛膜促性腺激素（β-hCG）和白细胞介素18（IL-18）联合检测对子痫前期的预测价值。方法以确诊的48例子痫前期为观察组，其中轻度子痫前期22例，重度子痫前期患26例，以正常的妊娠孕妇48名为对照组，采用酶联免疫吸附试验法检测血清中PLGF、PP13、β-hCG和IL-18的含量，并评价组间差异及单样本和联合检测的灵敏度、特异性和ROC曲线下面积。结果联合检测结果的敏感性、特异性以及曲线下面积均高于指标单独检测结果，对轻度子痫前期患者和重度子痫前期患者筛查的敏感性分别为95.5%和88.5%，特异性分别为为97.9%和100%，曲线下面积分别为0.966和0.948。结论血清联合检测的诊断准确率、敏感性及特异性较高，对子痫前期的预测有重要的参考价值。
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