Objective:To glargine combined repaglinide treatment of type 2 diabetes observed in clinical efifcacy.Methods: Our hospital from January 2013 to January 2014 treated over 168 patients with type 2 diabetes were randomly divided into study group and the control group, the study group using insulin glargine combined with repaglinide therapy, the control group with pre-mixed insulin therapy. Body mass index was observed after 16 weeks test study group and the control group, hematuria hemoglobin, serum uric acid levels and insulin levels and so on. Two groups of patients before and after treatment.Results:Hematuria hemoglobin, serum uric acid levels and insulin levels were signiifcantly different (P<0.05), the total efifciency of the two groups of patients, the incidence of hypoglycemia differences were statistically signiifcant (P<0.05 ). Conclusion:Glargine combined with repaglinide treatment of type 2 diabetes, obtain better clinical efifcacy and safety, should be widely applied in clinical practice.%目的：甘精胰岛素联合瑞格列奈治疗2型糖尿病临床疗效观察。方法：将我院2013年1月-2014年1月收治过的168例2型糖尿病患者随机分为研究组与对照组，其中研究组采用甘精胰岛素联合瑞格列奈治疗，对照组采用预混胰岛素治疗。16周后观察测试研究组与对照组的体质指数、血尿血红蛋白、血清尿酸水平以及胰岛素水平等情况。结果：两组患者治疗前后血尿血红蛋白、血清尿酸水平以及胰岛素水平差异均有统计学意义(P<0.05)，两组患者治疗后总有效率、低血糖发生率差异均具有统计学意义(P<0.05)。结论：甘精胰岛素联合瑞格列奈治疗2型糖尿病，可获得较佳的临床疗效与安全性，在临床上值得推广应用。
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