Objective To study the protection of Tanreqing Injection against lung injury in mice induced by respiratory syncytial virus, and discuss its mechanism. Methods Balb/c mice were randomly divided into normal group, viral infection group, ribavirin (100 mg/kg) group, and Tanreqing Injection (2, 4, and 8 mL/kg) groups, and each group had 10 rats. After infected by respiratory syncytial virus, drugs were tail iv administered with volume of 1 mL/100 g, once daily, and all animals were treated for 8 d. Lung index and lgTCID50 were detected, pathological changes of lung tissue were observed, level of MDA, GSH and activity of IFN-γwere determined, and T lymphocyte translation faction and IL-2 activity were detected. Results After treatment of Tanreqing Injection, compared with infection group, lung index and lgTCID50 of Tanreqing Injection (2, 4, and 8 mL/kg) groups were obviously decreased (P < 0.05), and lung injury were improved. Compared with infection group, levels of MDA, GSH were significantly decreased, activity of IFN-γand SI were significantly increased (P<0.05). Conclusion Tanreqing Injection has protection against lung injury in mice induced by respiratory syncytial virus, which might be related to improvement of immune response ability.%目的：研究痰热清注射液对呼吸道合胞病毒感染小鼠肺损伤的保护作用，并探讨其作用机制。方法 Balb/c小鼠随机分为对照组、感染组、利巴韦林（100 mg/kg）组和痰热清注射液（2、4、8 mL/kg）组，每组10只。呼吸道合胞病毒滴鼻感染后，尾iv给予相应剂量的药物，给药容积为1 mL/100 g，1次/d，连续给药8 d。计算肺指数，测定肺组织悬液lgTCID50，观察肺组织病理学改变，测定MDA、GSH含量和IFN-γ活性，检测T淋巴细胞转化功能和IL-2活性的变化。结果经痰热清注射液治疗后，与感染组比较，痰热清注射液2、4、8 mL/kg组小鼠肺指数、lgTCID50明显降低（P＜0.05），呼吸道合胞病毒损伤小鼠肺组织病理状态得到改善。与感染组比较，痰热清注射液2、4、8 mL/kg组小鼠MDA水平、GSH水平明显降低，IFN-γ活性明显升高，SI明显升高（P＜0.05）。结论痰热清注射液对呼吸道合胞病毒感染小鼠的肺损伤具有保护作用，其机制可能与提高机体免疫应答能力有关。
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