Miscibility of the fibroin, which was soluble in CaCl-2|H-2O|C-2H-5OH aqueous solution, mixed with chitosan was investigated, and its microspheres were prepared. The chitosan (CS)/fibroin (FB) microsphere inclusion fenoprofen calcium (CS|FB|FC) was prepared, and its structure was analyzed by FTIR, X|ray and SEM. The results indicated that blend of chitosan, fibroin and fenoprofen calcium in aqueous solution is miscible, and strong interaction caused by intermolecular hydrogen bonding exits in CS|FB|FC. It was indicated that approximately 77% of fenoprofen from the microsphere were released in phosphate|buffered saline(pH=7.4) within the initial 6h, and with increasing the glutaraldehyde concentration, the release of fenoprofen decreased.
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