N-(4,4'-二氟苯甲基)哌嗪的合成

摘要

N-(4,4’-Difluorobenzhydryl)piperazine, a key intermediate of lomerizine hydrochloride, was synthe-sized from piperazine hydrochloride via neutralization and condensation with 4,4’-difluorobenzhydrylchloride with an overallyield of 70.4%。