New spinosin derivatives from the seeds of Ziziphus mauritiana

摘要

Three new acylated flavonoid C-glycosides,6'''-(-)-phaseoylspinosin(1),6'''-(3'''',4'''',5''''-trimethoxyl)-(E)-cinnamoylspinosin(2),and 6'''-(4''''-O-β-D-gluco-pyranosyl)-benzoylspinosin(3),were isolated from the seeds of Ziziphus mauritiana(Rhamnaceae).A further 19 known compounds including eight spinosin analogues(4-11)were also isolated.Their structures were elucidated by means of spectroscopic analysis and chemical method.Among spinosin derivatives 1,2,4,7,8,and triterpenoid saponin 14,jujuboside A(14)displayed moderate acetylcholinesterase(AchE)inhibitory activity with an inhibition value of 46.2%at a concentration of 1μM.