Association of family history with long-term prognosis in patients undergoing liver resection of HBV-related hepatocellular carcinoma

摘要

Background:Family history is a risk factor for the development of hepatocellular carcinoma(HCC).The aim of the current study was to investigate the association between family history of HCC and long-term oncologic prognosis among patients undergoing curative liver resection for hepatitis B virus(HBV)-related HCC.Methods:Patients who underwent curative liver resection of HBV-related HCC between 2003 and 2013 were consecutively enrolled.Family history was defined as a self-reported history of HCC in a first-degree relative.Propensity score matching(PSM)and multivariable Cox-regression analyses were performed to compare overall survival(OS)and recurrence-free survival(RFS)among patients with and without a family history.Results:Among 1,112 patients,183(16.5%)patients had a family history of HCC.Using PSM,179 pairs of patients with and without a family history were created that had no differences in the baseline characteristics and operative variables.On matched analysis,family history was associated with decreased OS and RFS after curative-intent resection of HBV-related HCC in the propensity matching cohort(P=0.042 and 0.006,respectively).On multivariable Cox-regression analyses,a family history of HCC was associated with decreased OS(HR:1.574;95%CI:1.171–2.116;P=0.003)and RFS(HR:1.534;95%CI:1.176–2.002;P=0.002)after adjusting for other prognostic risk factors.Conclusions:Family history was associated with decreased OS and RFS rates among patients undergoing curative liver resection of HBV-related HCC.