中孕期产前超声筛查在胎儿神经管缺陷中的应用价值

摘要

Objective To evaluate the clinical value of ultrasound screening for fetal central nerve system abnormalities in second trimester.Methods During the period of Feb. 2008 and Sep. 2013 2 661 pregnancy women were subjected to ultrasound screening in second trimester in our hospital. The structures, such as the head and spine were scanned in detail.ResultsEighty-seven fetus with fetal central nerve system abnormalities were examined prenatally by ultrasound and each showed typical imaging feature. Among these cases, there were 32 cases of hydrocephalus, 5 cases of holoprosencephaly, 11 cases of anencephaly, 8 cases of choroid plexus cysts, 6 cases of cephalocele, 19 cases of spina biifda, 1 cases of iniencephaly, 3 cases of Dandy-Walker complex and 2 cases of scoliosis. The cases of no more than 5 temporarily were not discussed in this paper.Conclusion Ultrasound screening in second trimester is of great value to screen fetal abnormality, which can reduce the risk of medical treatment in fetal abnormality screening.%目的：探讨中孕期产前超声筛查在胎儿神经管缺陷中的应用价值。方法2008年2月～2013年9月间，参考国际妇产超声学会（ISUOG）操作规范，对2661例孕妇进行了中孕期产前超声筛查，系统检查胎儿头颅、脊柱等结构。结果2661例胎儿中共检出胎儿神经管缺陷81例，其中脑室扩张32例，前脑无裂畸形5例，无脑儿11例，脉络膜囊肿8例，脑脊膜膨出6例，脊柱裂19例。结论中孕期产前超声筛查能够最大限度地检出胎儿神经管畸形，对减少漏诊率、降低医疗风险具有重要的临床意义。