Objective To investigate the efficacy and safety of recombinant thermal perfusion chemotherapy combined with transcatheter arterial embolization (TAE) on liver neoplasm. Methods Totally 192 cases of liver neoplasm were randomly divided into treatment group and control group. The treatment was repeated every month. After three therapeutic cycles, the clinical effect was evaluated with RECIST criteria and the living quality was assessed with Karnofsky scoring. Results No CR was obsered in two groups. The control rate of disease and the Karnofsky score were significantly higher in treatment group than those in control group three months later (P<0.05), Adverse reactions were mild and no significant difference between two groups (P>0.05). Conclusion Thermochemotherapy combined with TAE in patients with liver neoplasm can further improve the short-term quality of life efficacy and disease control rate. It is safe with few adverse effects and a worthwhile treatment for clinical application, and long-term efficacy and safety will be observed furtherly.% 目的探讨热灌注化疗联合肝动脉栓塞(TAE)治疗肝癌的有效性及安全性.方法192例肝癌随机分为治疗组和对照组，治疗组采用热灌注化疗联合TAE治疗，对照组常规TACE治疗，两次治疗间隔1个月.3个周期后，按照RECIST标准评价疗效，参照Karnofsky评分(KPS)变化评价生活质量(QOL).结果两组术后均无CR患者，治疗组在有效率(RR)、疾病控制率(DCR)及QOL方面与对照组比较差异均有统计学意义(P<0.05).不良反应两组差异无统计学意义(P>0.05).结论热灌注化疗联合TAE治疗肝癌近期可以改善患者生活质量，提高治疗有效率及疾病控制率，且副作用小，安全性好，值得临床上进一步推广应用，长期疗效有待进一步观察.
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