饮用水氟碘正常区碘氟排泄相关性研究

摘要

Objective To study the change of urine fluoride excretion after decreasing the iodine intake in the arer where the iodine and fluorine content is normal. Methods Stop iodized salt supply of 360 residents at the survey point for two nonths.Determine the urine fluoride and urine iodine when the study beginning ang two months later.Analysis the correlation. Results After stopping to supply iodized salt, median urine iodine paired difference is 95.86μg/L, t=7.78,P<0.01. The median urine fluoride paired difference is-0.15 mg/L,t=-3.31,P<0.01. Conclusion After stopping to supply iodized salt, urine iodine content of the study population significantly reduced. At the same time, the urine fluoride content increased significantly and there is no difference between male and female. The results show that the discharge between iodine and fluoride in the body can antagonistic each other.%　　目的研究饮用水氟碘正常区降低碘摄入量对氟的排泄的影响。方法对调查点饮用水氟碘正常区人群360户居民停供碘盐两个月，测定停碘开始及2个月时尿氟、尿碘含量，分析相关性。结果停供碘盐后，尿碘配对差值中位数为95.86μg/L，t=7.78,P<0.01。尿氟配对差值中位数为-0.15 mg/L，t=-3.31,P<0.01。结论停供碘盐后，调查点人群尿碘含量显著降低，同时，尿氟含量显著增加，性别间无差异，表明碘和氟在体内的排出有相互拮抗作用。