摘要：
Objective To study the benchmark dose (BMD) of fluoride concentration in saliva,and to evaluate the significance of saliva fluoride on control and prevention of endemic fluorosis.Methods In September 2014,middle school students in endemic fluorosis areas and non-endemic fluorosis areas in North China Petoleum were selected as objects.The contents of fluoride in water,urine and saliva were determined.The correlation of fluoride content in water,urine fluoride and fluoride concentration in saliva was analyzed.According to the levels of the saliva fluoride concentration,the children were divided into 11 groups,＜ 1.00,1.00-,2.00-,3.00-,4.00-,5.00-,6.00-,7.00-,8.00-,9.00-and ≥ 10.00 mg/L.The prevalence of dental fluorosis and defected dental fluorosis were investigated and the saliva fluoride concentration was calculated by Banch-Mark Dose Software.Results Compared with non endemic areas,the fluoride contents in water,urine and saliva [(2.13 ± 0.13),(1.29 ±0.73),(4.01 ± 3.61) mg/L] were higher than that in endemic areas [(0.67 ± 0.13),(0.38 ± 0.08),(0.75 ± 0.12) mg/L,t =158.730,24.780,18.114,all P ＜ 0.01].The fluoride concentration in saliva was positively correlated with the fluoride content in water and urine in endemic areas (r =0.626,0.945,all P ＜ 0.01).The (BMDs and benchmark dose lower bound (BMDLs) were 0.91,0.54,3.72,3.32 mg/L respectively,calculated by Banch-Mark Dose Software.With the increase of fluoride concentration in saliva,the prevalence of dental fluorosis and defect dental fluorosis had increased too,especially when the fluoride content in saliva was more than 4 mg/L.There were significant doseresponse relationships between the urine fluoride and the prevalence of dental fluorosis and defected dental fluorosis.Conclusion The fluoride concentration in saliva could be used as one of the evaluation indexes of fluorosis,and the BMD of saliva fluoride concentration in endemic fluorosis areas is suggested as 0.91 mg/L.%目的 探讨唾液氟的基准剂量(BMD)及其在地方性氟中毒防治中的应用.方法 2014年9月,选择河北沧州任丘华油供应(病区)和井下(非病区)的中学在校生作为调查对象,测定饮用水水氟、调查对象尿氟及唾液氟含量,对水氟、尿氟及唾液氟含量进行相关分析,按照唾液氟含量分组:＜1.00、1.00～、2.00～、3.00～、4.00～、5.00～、6.00～、7.00～、8.00～、9.00～及≥10.00 mg/L,共11组,分别计算各组氟斑牙和缺损型氟斑牙的患病率,用Banch-Mark Dose Software(美国环境保护署开发的基准剂量计算软件)计算唾液氟含量的BMD.结果 病区的水氟、尿氟及唾液氟含量[(2.13±0.13)、(1.29±0.73)、(4.01±3.61)mg/L]高于非病区[(0.67±0.13)、(0.38±0.08)、(0.75±0.12)mg/L,t=158.730、24.780、18.114,P均＜0.01];病区的唾液氟含量与水氟、尿氟含量正相关(r=0.626、0.945,P均＜0.01);Banch-Mark Dose Software计算儿童唾液氟含量的BMD和其95％可信区间下限值(BMDL)分别为0.91、0.54,3.72、3.32 mg/L,随着唾液氟含量的增加,氟斑牙患病率和缺损型氟斑牙患病率逐渐增加,在唾液氟含量≥4 mg/L以上时上升较快,呈较明显的剂量-反应关系.结论 唾液氟的基准剂量可作为地方性氟中毒的评价指标之一,建议儿童唾液氟的BMD为0.91 mg/L.
