早发型子痫前期孕妇解痉抗凝治疗的临床研究

摘要

Objective To investigate the effectiveness between the magnesium sulfate combined with low molecular heparin therapy and magnesium sulfate conventional treatment for early-onset preeclampsia. Methods 64 cases of early onset preeclampsia patients were randomly divided into 2 groups, magnesium sulfate conventional treatment group and magnesium sulfate combined with low molecular heparin (4100 U daily). The clinical symptoms and signs as well as laboratory data were collected and analyzed to evaluate the therapeutic effectiveness. Results There was no statistical difference in clinical index among 2 groups pre-treatment (P>0. 05). The rate of neonatal asphyxia in magnesium sulfate combined with low molecular heparin was significantly lower than magnesium sulfate conventional treatment group post-treatment (P>0.05). Conclusion Magnesium sulfate combined with low olecular heparin can significantly improve the neonatal outcomes in early onset reeclampsia.%　　目的对比早发型子痫前期患者应用硫酸镁合并低分子肝素联合治疗与常规硫酸镁治疗的临床疗效.方法将64例早发型子痫前期患者随机分为2组，研究组应用硫酸镁+低分子肝素(4100 U/d)治疗；对照组采用硫酸镁常规治疗.通过临床表现及实验室检查的变化判断疗效.结果两组患者在治疗前临床各项指标差异无统计学意义(P>0.05)；两组治疗后平均动脉压与24小时尿蛋白均较治疗前下降(P<0.05)，但组间差异无统计学意义(P>0.05)；治疗后研究组的新生儿窒息率较对照组显著降低，差异有统计学意义(P<0.05).结论硫酸镁联合低分子肝素治疗可明显改善早发型子痫前期患者新生儿的预后.