探讨ERCP(endoscopic retrograde cholangiopancreatography，ERCP)术后并发胰腺炎的危险因素，以更好的预防ERCP术后胰腺炎的发生。方法收集2010年10月～2013年7月于山西医科大学第一附属医院住院行ERCP检查或治疗的168例患者的住院资料，符合标准153例，采用单因素及多因素分析方法分析患者性别、年龄、肥胖、黄疸、麻醉方式、插管次数、胰管显影次数、怀疑乳头括约肌功能障碍、乳头括约肌切开、鼻胆管引流、胆管支架置入等因素与ERCP术后胰腺炎发生的关系。结果153例行ERCP术患者中发生胰腺炎19例，发生率为12.42%。单因素分析显示在所选择的25个因素中有9个因素有统计学意义，将有统计意义因素行多因素非条件Logistic回归分析，筛选出4个变量，其中女性、怀疑乳头括约肌功能障碍、插管困难为ERCP术后胰腺炎的独立危险因素、而鼻胆管引流为ERCP术后胰腺炎的保护因素。结论女性、怀疑乳头括约肌功能障碍、插管困难是ERCP术后胰腺炎的高危因素，而鼻胆管引流可预防ERCP术后胰腺炎的发生。%Objective To investigate the risk factors of post-ERCP pancreatitis,so we can better prevent.Methods We collected information of the 168 patients who hospitalized in thefirst affiliated hospital of shanxi medical university from October 2010 to July 2013 to undergo ERCP examination or treatment. Finally 153 cases were conformed to the standard. We analyzed the relationship of gender, age, obesity, jaundice, anesthesia, number of intubation, numuber of pancreatic duct image, suspected sphincter of Oddi dysfunction, papillary sphincter incision, nose bile duct drainage, bile duct stenting and post-ERCP pancreatitis by single and multiple factors analysis.Results 19 of 153 patients who underwent ERCP surgery occurred pancreatitis. The rate was 12.42%. 9 of25 factors showed statistical significance in single factor analysis. We take the 9 facters in unconditioned Logistic regression analysis and select four variables.The result shows women, suspected papillary muscle dysfunction, difficult intubation was independent risk factors for post-ERCP pancreatitis, and nasal biliary drainage was protection factor of post-ERCP pancreatitis. Conclusion Women, suspected sphincter of Oddi dysfunction, difficult intubation are risk factors of post-ERCP pancreatitis, and nasal biliary drainage can prevent the occurrence of post-ERCP pancreatitis.
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