康艾注射液联合化疗治疗老年晚期非小细胞肺癌疗效观察

摘要

Objective To observe the effect of Kangai injection combined with TP regimen(paclitaxel+cisplatin) in the treatment of elderly patients with advanced non-small cell lung cancer,Methods 56 cases of metastatic lung cancer patients were divided into two groups,28 cases of the control group,Two groups were used tp chemotherapy, 21 days was a period ,the treatment continued for 2 cycles, the observation group started chemotherapy Aikang needle injection 50 mLKang ai into 5%dextrose injection, intravenous infusion of 1 day, 14 days was a cycle, chemotherapy term efficacy after two cycles of chemotherapy, the incidence of adverse reactions in patients with chemotherapy, bone marrow suppression situation were observed. Results Term effect of observation group (CR+RR) was 53.83,in the control group term efficacy (CR+RR) was 35.70%, the difference was not statistically significant, but the observation group was significantly higher quality of life to improve the situation, the difference was statistically significance (P<0.05);bone marrow suppression control group situation, leukopenia extent, the degree of anemia than those on the observation group was significantly, with statistical significance (P<0.05);groups of patients after chemotherapy, no significant difference in platelet changing circumstances;total incidence of gastrointestinal toxicity in observation group during chemotherapy was 17.86%, and all wasⅠ-Ⅱdegree,gastrointestinal adverse reactinos in the control group was 42.86%,there was a statistically significant difference between the two groups (P<0.05), body mass after chemotherapy increased in observation group than in the control group, with statistical significance (P<0.05).Conclusion Kang'ai injection combined with chemotherapy can enhance the efficacy of chemotherapy, reduce chemotherapy pain and improve patient quality of life.%目的：观察康艾注射液联合TP方案（紫杉醇＋顺铂）方案治疗老年晚期非小细胞肺癌临床效果。方法将南阳医学高等专科学校第一附属医院收治的56例老年晚期肺癌患者随机分为观察组和对照组，两组各38例。两组均采用TP方案化疗，21 d为1个周期，共治疗2个周期，观察组自化疗开始时即联用复方康艾针，康艾注射液50 ml入5%葡萄糖注射液，静滴1次/d，每周期14 d，观察化疗2个周期后化疗近期疗效、患者化疗不良反应发生情况、骨髓抑制情况。结果观察组近期疗效（CR+RR）为53.83%，对照组为35.70%，差异无统计学意义，但观察组生活质量改善情况明显高于对照组，差异有统计学意义（P＜0.05）；对照组骨髓抑制情况、白细胞下降程度、贫血程度均较对观察组明显，差异有统计学意义（P＜0.05）；两组患者化疗后血小板改变情况差异无统计学意义；观察组化疗过程中消化道毒性总发生率为17.86%，且多为Ⅰ～Ⅱ度，对照组消化道不良反应发生率为42.86%，两组比较差异有统计学意义（P＜0.05），化疗后体重增加情况观察组较对照组明显，差异统计学意义（P＜0.05）。结论康艾注射液联合化疗、减轻化疗痛苦、改善患者生活质量。