右美托咪定不同给药方式麻醉在妇科腹腔镜手术中的麻醉效果分析

摘要

目的：探讨右美托咪定不同给药方式麻醉在妇科腹腔镜手术中的麻醉效果。方法选择择期接受腹腔镜子宫肌瘤切除手术治疗患者120例，随机均分为右美托咪定单次静脉注射组(DS组)、右美托咪定持续静脉泵注组(DC组)和对照组(C组)（n=40），比较3组的麻醉效果及不良反应。结果与C组比较，DS组和DC组气腹建立后HR、MAP均较稳定，尤其是DS组的HR稳定性更好（P<0.05）。DS组和DC组心动过速、恶心及呕吐发生率均显著低于C组（P<0.05），DS组心动过缓发生率显著低于DC组（P<0.05）。结论临床进行妇科腹腔镜手术过程中，在实施麻醉诱导前单次静脉注射右美托咪定0.6μg/kg，能有效降低患者术后恶心、呕吐等不良反应，缓解患者血流动力学波动，促进患者术后恢复，且不增加术后心动过缓等发生率。%Objective To investigate the effect of dexmedetomidine administered at different administration in gynecological laparoscopic operation.Methods 120 cases of patients in department of gynaecology Henan Province Tumor Hospital gynecologic who accepted laparoscopic resection of uterine fibroids were randomly divided into right dexmedetomidine midazolam order intravenous injection group (DS group) and dexmedetomidine set continuous intravenous infusion group (DC group) and control group (Group C) group (n=40). Anesthesia effect and adverse reaction were compared with between three groups.Results Comparing with C group, HR after the establishment of pneumoperitoneum in DS group and DC group, MAP were stable, especially HR stability of DS group (P<0.05). The incidence of tachycardia, nausea and vomiting in DS group and DC group were signiifcantly lower than that in group C (P<0.05), and the incidence of tachycardia in group DS was signiifcantly lower than that in DC group (P<0.05).Conclusion Before anesthesia induction, giving a single intravenous dexmedetomidine 0.6μg/kg can effectively reduce postoperative nausea, vomiting and other adverse reactions, relieving the lfuctuation of the blood lfow dynamics in patients, promoting postoperative recovery and it does not increase the incidence of postoperative cardiac tachycardia.