丁苯酞软胶囊治疗血管性痴呆精神心理量表评分的变化及临床疗效观察

摘要

Objective To observe the effect and safety of Butyiphthalide Soft Capsules in treatment of vascular dementia ( VD), and to research the probable mechanisms.Methods 100 mild and moderate VD patients were randomly divided into Butylphthalide group and Nimodipine group.Both groups were treated for 3 months.Efficacy was assessed by MMSE, ADL and CDR scale 1 day before treatment and in the 2nd, 4th and 12th weeks after treatment.The improvement of symptom and safety of drug use were evaluated before and after treatment.Results There was significant difference of scale in both groups before and 12 weeks after treatment( P ＜0.05), and there was significant difference between the two groups( P ＜0.05 ); the total effect rate in Butylphthalide group was 84.9％ ,while 64.0％ in Nimodipine group, There was significant difference between the two groups( P ＜0.05 ), but the incidences of adverse events in the two groups showed no significant difference ( P ＞ 0.05).Conclusion Butylphthalide Soft Capsules is more effective in treating mild and moderate VD than Nimodipine, and is safe to clinical application.%目的 观察丁苯酞软胶囊治疗血管性痴呆(vascular dementia, VD)对精神心理量表的影响及疗效.并探讨可能的机制.方法 将明确诊断为轻中度VD的100例随机分为丁苯酞组和尼莫地平组.两组均治疗3个月,于用药前1 d、用药后2周、4周、12周分别行简易精神状态检查(MMSE)、日常生活能力量表(ADL)、临床痴呆程度量表(CDR),观察治疗前后症状的改善情况及药物使用的安全性.结果 治疗12周后,两组各量表评分与组内治疗前比较差异均有统计学意义(P＜0.05),两组组间比较差异有统计学意义(P＜0.05).丁苯酞组总有效率84.0%,尼莫地平组总有效率64.0%,两组比较差异有统计学意义( P＜0.05),两组不良反应发生率差异无统计学意义.结论 丁苯酞软胶囊对轻中度VD的治疗效果优于尼莫地平,临床应用安全.