观察不同病情分期白癜风外周血T淋巴细胞亚群表达水平

摘要

Objective To investigate the immunologic correlation of vitiligo in different stagings.Methods A total of 52 patients with vitiligo (group A) whom included 17 patients in progressive stage and 35 in stable phase,and 30 healthy blood donors (group B) were added to the study.The T cells in peripheral blood and subgroup were detected by monoclonal antibodies and indirect immunofluorescence staining method.Results The CD4 + T lymphocyte of group A was decreased compared with that of group B,and the difference was statistically significant (P ＜ 0.01).The CD4 + and the CD8 + T lymphocytes of group A in progressive stage were significantly decreased compared with those of group B (P ＜0.05) ; the CD4+ T lymphocyte of group A in stable phase was significantly decreased,while the CD8 + T lymphocyte was significantly increased (P ＜0.05).Conclusion Patients with vitiligo have immune deficiency.There is a close correlation between immunity function and the advance of pathogenetic condition.%目的 探讨不同病情分期白癜风的免疫相关性.方法 选择白癜风52例(白癜风组),其中进展期17例,稳定期35例；选择同期健康献血者30例(对照组).均采用单克隆抗体间接免疫荧光法检测外周血T细胞及其亚群并进行比较.结果 白癜风组与对照组比较,仅CD4+T细胞显著降低,差异有统计学意义(P＜0.0l).进展期患者外周血CD4+、CD8+T细胞较对照组显著降低,差异有统计学意义(P＜0.05)；稳定期患者外周血CD4+T细胞较对照组显著降低,CD8+T细胞显著升高,差异有统计学意义(P＜0.05).结论 白癜风患者存在免疫缺陷,病情进展与否与其自身的免疫功能密切相关.