隐匿性乙型肝炎病毒感染的机制及其对血液安全的影响

摘要

血清匀月泽A早阴性者肝组织或血清中仍可检出匀月灾阅晕A，此现象称为隐匿性匀月灾感染(occult hepatitis B virus in-fection，韵月陨)。韵月陨对保障输血安全、临床诊断和匀月灾流行病学监控带来很大困难，进一步阐明其机制有利于韵月陨的预防和治疗。本文综述了近年来对韵月陨发生机制的研究进展、韵月陨对血液安全的影响以及核酸检测工作对血液安全的促进作用。%HBV DNA can be detected in one's serum or liver who is HBsAg negative in serum, and this phenomenon is called occult hepatitis B virus infection (OBI). OBI makes it particularly difficult to ensure blood transfusion safety, make clinical diagnosis and imple-ment epidemiological monitoring of HBV. Further study for the mechanism is beneficial for its prevention and treatment. This paper re-viewed the research progress of the mechanism of OBI in recent years, the impact on blood safety, and the promoting effect on blood safety of nucleic acid test.