注射用盐酸川芎嗪对急性冠脉综合征患者血清TNF-α、IL-8及CRP的影响

摘要

Objective To investigate the impact of ligustrazine hydrochloride injection on TNF-α, IL-8 and CRP in patients with acute coronary syndrome (ACS). Methods From December 2013 to December 2015, 80 ACS patients treated in our hospital were randomly and equally divided into two groups. The control group was given symptomatic treatment, the observation group was given ligustrazine hydrochloride injection on this basis. The clinical treatment effects, changes of serum TNF-α, IL-8 and CRP levels before and after treatment in two groups were observed. Results The total effective rate in observation group was 95.0%, significantly higher than 70.0%in control group (P <0.05). Before treatment, the serum TNF-α, IL-8 and CRP levels in two groups had no statistical difference (P >0.05); after treatment, the serum TNF-α, IL-8 and CRP levels in two groups decreased significantly, and the decline degree of observation was more obvious (P<0.05). Conclusions Ligustrazine hydrochloride injection in treatment of ACS patients can significantly reduce the activity of inflammatory cytokines and improve efficacy.%目的：探讨注射用盐酸川芎嗪对急性冠脉综合征患者血清TNF-α、 IL-8及CRP的影响。方法选取2013年12月至2015年12月在我院治疗的80例急性冠脉综合征患者随机均分为两组。对照组给予对症治疗，观察组在此基础上施加注射用盐酸川芎嗪治疗。观察两组的治疗效果以及治疗前后血清TNF-α、 IL-8及CRP水平的变化。结果观察组治疗总有效率为95.0%，显著高于对照组的70.0%（P<0.05）。治疗前两组血清TNF-α、 IL-8、 CRP水平比较差异不显著（P>0.05）；治疗后两组血清TNF-α、 IL-8、 CRP水平均明显降低，且观察组降低程度更加显著（P<0.05）。结论使用注射用盐酸川芎嗪对急性冠脉综合征患者进行治疗可以明显降低炎性细胞因子的活性，提高疗效。