Relationship between Serum Lipid Index, C Reaction Protein (CRP), Insulin Resistance and Coronary Artery Disease in Diabetes Mellitus Patients Complicated with Coronary Atherosclerotic Heart Disease (CAHD) and Correlation Analysis

摘要

Objective: To investigate the relationship between serum lipid index, C Reaction protein (CRP), insulin resistance level and coronary artery disease (CAD) in patients with diabetes mellitus (DM) complicated with coronary atherosclerotic heart disease (CAHD) and its correlation. Method: Select 62 CAHD patients identified by coronary artery angiography in January 2015-January 2016 as DM group, 60 non-DM CAHD patients as NDM group, and 60 contemporary healthy people as control group, determine its blood glucose (GLU), insulin sensitivity index (ISI), level of insulin resistance (HOMA-IR), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), and CRP level. Results: The incidence rate of multi-vessel in DM group is higher than that in NDM group (P<0.05); The levels of TC, TG, LDL, GLU, HOMA-IR and CRP in DM group are higher than that in NDM group and control group (P<0.05), while HDL and ISIS levels are lower (P<0.05); the levels of TC, TG, LDL, GLU, HOMA-IR and CRP in 3-vessel lesion group are significantly higher than that in 2-vessel lesion group and control group (P<0.05), while the levels of HDL and ISI are lower (P<0.05); By level correlation analysis, we found that the number of lesion artery is positively correlated with TC, TG, LDL, GLU, HOMA-IR, CRP levels (P<0.05), and negatively correlated with HAL, ISI level (P<0.05). Conclusion: Most CAHD patients exists severe lipid metabolism disorders, insulin resistance and inflammatory reaction, and its incidence level is related with the degree of coronary artery lesion, which may be the risk factors of coronary heart disease.