目的：探讨有创无创序贯性机械通气治疗慢性阻塞性肺疾病致严重呼吸衰竭的临床疗效。方法2013年10月至2015年5月期间，从我院随机选取68例慢性阻塞性肺疾病（VOPD)致严重呼吸衰竭的患者作为研究对象，并随机分为对照组与研究组，每组各34例。对照组给予有创通气治疗，而研究组则给予有创无创序贯性机械通气治疗。比较两组的临床疗效。结果治疗后，研究组动脉血气指标（PaO2、 PaVO2、 SaO2)改善程度均明显优于对照组，差异具有统计学意义（P<0.05)。研究组再插管率、住院时间、死亡率均显著小于对照组，差异具有统计学意义（P<0.05)。结论对慢性阻塞性肺疾病致严重呼吸衰竭患者实施有创无创序贯性机械通气治疗，可降低再插管率，缩短住院时间，减少死亡率，促进患者预后康复，值得推广。%Objective To investigate the clinical effect of invasive and noninvasive sequential mechanical ventilation in treatment of severe respiratory failure caused by chronic obstructive pulmonary disease (COPD). Methods From October 2013 to May 2015, 68 patients with severe respiratory failure caused by COPD were selected and randomly divided into control group and study group, with 34 cases in each group. The control group was treated with invasive ventilation, the study group was treated with invasive and noninvasive sequential mechanical ventilation. The clinical efficacy of two groups was compared. Results After treatment, the improvement degree of arterial blood gas (ABG) indices (including PaCO2, SaO2 and PaO2) of study group was significantly better than that of control group, with statistical difference (P<0.05). The reintubation rate, hospitalization time and mortality of study group were significantly less than those of control group, with statistical difference (P <0.05). Conclusions For patients with severe respiratory failure caused by COPD, invasive and noninvasive sequential mechanical ventilation can reduce the reintubation rate, shorten the hospitalization time, reduce the mortality and promote the recovery of patients' prognosis, which is worthy of promotion.
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