尿路感染的发病机制以及卡介苗对膀胱癌的预防作用,暗示将膀胱作为一个独特的黏膜表面研究的重要性.细菌感染膀胱后微环境如何产生适应性免疫.过去膀胱曾经被广泛认为是无菌的环境,这个概念在最近受到动摇,提示需要对尿路病原体感染或卡介苗免疫应答的影响进行深入研究.本文就已经被阐述的膀胱生物学,并探索和定义亟待发掘的膀胱器官免疫学进行综述.%Objective The pathogenesis of urinary tract infection and the preventive effect of Bacillus Calmette Guerin on bladder cancer imply the importance of bladder as a unique mucosal surface research. This article discussed that after bladder infected by bacteria,the way in which the microenvironment produce adaptive immunity. Once in the past, bladder is widely considered to be a sterile environment, the concept has been recently shaken. It is suggested that we should further study the influence of urinary tract pathogen infection or BCG immune response. In this paper, bladder biology has been illustrated, and bladder organ immunity is urgently needed to be explored and defined.
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