心肌肌钙蛋白I、肌钙蛋白T、肌酸激酶同工酶MB早期诊断 急性心肌梗死敏感性及特异性比较分析

摘要

目的探讨心肌肌钙蛋白I(cTnI)、肌钙蛋白T(cTnT)及肌酸激酶同工酶MB(CK-MB)早期诊断急性心肌梗死的临床应用价值。方法对60例急性心肌梗死(AMI)和40例不稳定型心绞痛(UA)患者的同一血样标本检测cTnI、cTnT、CK-MB3项指标，分别进行两组间比较，并对AMI组和UA组各指标作对比分析。结果cTnI、cTnT早期诊断急性心肌梗死灵敏度高于CK-MB，阳性率分别为63.3%、46.7%、18.3%，[WTBXP＜0.01；cTnI和cTnT无显著差别，P＞0.05；cTnI、cTnT、CK-MB特异性相当，无显著差异。结论心肌肌钙蛋白I和肌钙蛋白T对于AMI的早期诊断具有较高灵敏度和较强特异性，是心肌损伤特异性标志物，cTnI检测方便、快捷、准确，具有较好的临床价值。%To observe the application value of cardiac troponin I(cTnI),cardiac troponin T (cTnT) and creatine kinase MB (CK-MB) for the early diagnosis of acute myocardial infarction (AMI).Methods The same serum sample was measured to detect the indexes of cTnI,cTnT and CK-MB levels in 60 patients with AMI and 40 patients with UA.Comparison between AMI and UA was performed and all the indexes were analysed contrastively.Results The sensitivity of cTnI and cTnT was higher than that of CK-MB,and their positive rates were 63.3%,46.7% and 18.3% respectively (P＜0.01) .There was no significant difference between cTnI and cTnI (P＞0 .05) and the specificity of the three indexes were almost the same without signi ficant difference.Conclusion cTnI and cTnT,as specific markers of cardiac damage,are more sensitive and specific in the early diagnosis of AMI. As a convenient,swift and accurate measurement method,cTnI has significant clinical value.