荔波瑶族、汉族雌激素受体α基因多态性与乙型肝炎病毒感染关系的研究

摘要

目的 研究荔波瑶族、汉族雌激素受体α(ESR1)基因多态性T29C位点与乙型肝炎病毒感染情况的相关性.方法 样本为荔波瑶族、汉族的隔离自然人群,采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)方法分析ESR1基因T29C位点多态性.结果 利用卡方检验对所调查人群的乙型肝炎感染与ESR1的T29C基因型的分布进行分析得出:ESR1 T29C基因多态性在瑶族、汉族男性乙型肝炎病毒(HBV)感染组与HBV非感染组中的分布差异有统计学意义,瑶族TT、TC、CC分别为49.0%、49.0%、2.0%vs 52.6%、29.0%、18.4%,汉族TT、TC、CC分别为31.6%、65.8%、2.6%vs 32.6%、37.2%、30.0%(P0.05).结论 ESR1的T29C基因多态性与汉族、瑶族乙型肝炎感染可能有相关,ESR1 T29C基因多态性可能是乙型肝炎易感性的因素之一.%Objective To investigate the association of estrogen receptor α (ESR1) polymorphism with susceptibility to hepatitis B virus(HBV) infection in Han nationality and Yap minority from Guizhou province. Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was used to detect the T29C polymorphism. Resells The association of estrogen receptor α polymorphism with susceptibility to hepatitis B virus infection:T29C polymorphisms were associated with HBV infection in Han , Yap's men(P 0.05). Conclusion ESRI's polymorphisms can influence the susceptibility to HBV infection in Guizhou's population. The research suggests that T29C polymorphisms may be a risk of factor for HBV infection.