Objective To evaluate the clinical value of myocardial contrast echocardiography(MCE) in detecting myocardial blood flow (MBF) of patients with syndrome X. Methods Thirty-five patients with syndrome X and thirty-two normal subjects were involved in the study. MCE was performed pre- and post-dobutamine injection. The peak video density(A) ,the re-turgor velocity of microvessel(J3) and the product of AX|3 were detected,and also the coronary flow reserve(CFR) was determined by myocardial contrast echocardiography. Results Before and after dobutamine stress test(DST) (3 and the product of AXp were larger after DST than those before DST in both groups,syndrome X patients respectively (0.83 + 0.13 vs 1. 34?. 26,(17. 66 + 3. 12) dB vs (31.42?. 98) dB;normal subjects (1. 68?0.16 vs 1. 89?. 19,(31. 06?. 25) dB vs (99. 97?. 35) dB( P <0. 05). And after DST, the (3 and the product of AXp of syndrome X patients were significantly lower than those of control group( P <0. 05). The CFR of syndrome X was significantly less than that of control group,1. 49?. 30 vs 3. 63?. 28 ( P <0. 01). Conclusion MBF could be analyzed quantitatively by MCE. MCE is useful for evaluating the microcirculation reserve abnormalities in syndrome X.%目的 探讨应用实时心肌声学造影(MCE)评估X综合征患者心肌血流量(MBF)的临床应用价值.方法 选择X综合征患者35例,对照组32例,分别在静息状态和多巴酚丁胺药物负荷试验后进行MCE检查,测量平台期心肌显影强度(A),曲线上升平均斜率(β)及A×β(MBF),并测定冠状动脉血流储备(CFR).结果 负荷前后两组β值和A×β值均较负荷前增加,差异有统计学意义,X综合征患者负荷前后(0.83±0.13 vs 1.34±0.26,(17.66±3.12) dB vs (31.42±3.98) dB;对照组负荷前后β值1.68±0.16 vs 1.89±0.19;A×β值负荷前后(31.06±3.25) dB vs (99.97±4.35) dB(P＜0.05),且负荷后X综合征组β值和A×β值低于对照组(P＜0.05),X综合征患者CFR降低,1.49±0.30 vs 3.63±0.28(P＜0.01).结论 实时心肌声学造影能定量分析MBF,可用于评价微循环灌注异常的X综合征患者.
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