老年人低密度脂蛋白胆固醇与死亡率相关的meta分析

摘要

目的 系统评价老年人低密度脂蛋白胆固醇(LDL-C)与死亡率之间的关系.方法 检索PubMed数据库、Cochrane临床试验数据库、中国知网CNKI、中国生物医学文献数据库CBM和万方数据库,检索时间从建库至2016年12月.筛选队列研究,且含有OR值及95％CI或可通过相关数据计算.结果 本次meta分析共纳入5篇文献,共包含50361例,高LDL-C作为参照组含3篇文章,RR=1.405,95％CI=1.206～1.635,P<0.01,低LDL-C作为参照组含2篇文章,RR=0.552,95％CI=0.506～0.602,P<0.01,不同浓度分析发现,老年人死亡风险随LDL-C浓度升高或降低呈反方向变化.结论 老年人LDL-C与死亡率之间存在负相关.%Objective To systematically evaluate the association between low-density lipoprotein cholesterol (LDL-C)and mortality.Methods The Pubmed,Cochrane Library,CNKI,CBM and Wangfang databases were searched from building databases to December 2016.The enrollment involved screening cohort studies with OR values and 95％ CI or the relevant data which can be calculated.Results Five studies with 50361 participants were finally included.High LDL-C as reference:the pooled RR was 1.405 (95％ CI = 1.206-1.635,P < 0.01 ).Low LDL-C as reference:the pooled RR was 0.552 (95％ CI = 0.506-0.602,P < 0.01 ).With the change of LDL-C,the risk of mortality became inverse.Conclusion High LDL-C is inversely associated with the all-cause mortality in the elderly.