初诊2型糖尿病患者HbA1c与血清MCP-1、MMP-9的相关性研究

摘要

Objective To explore the correlation of serum levels of MCP-1, MMP-9 and HbA1c level in the newly di-agnosed patients with type 2 diabetes and its clinical value. Methods The HbA1c level and serum levels of MCP-1 and MMP-9 were detected in 103 patients with newly diagnosed type 2 diabetic patients (diabetic group) and 103 healthy vol-unteers (control group) over the same period, and their correlation analysis were performed. Results The HbA1c level and serum levels of MCP-1 and MMP-9 were all significant higher in the diabetic group than those in the control group (t=17.04,7.23,10.28,P<0.05). In addition, serum levels of MCP-1 and MMP-9 in patients with diabetes were both posi-tively correlated with HbA1c(r=0.75,0.74,P<0.05). Conclusion Even for patients with newly diagnosed type 2 diabetes, a comprehensive screening is needed to assess the presence or absence of diabete-related complications and risks. HbA1c monitoring may also indirectly reflect the inflammatory intensity of immune response and occurrence of complications.%目的：探讨初诊2型糖尿病患者糖化血红蛋白A1c（HbA1c）与血清单核细胞趋化蛋白-1（MCP-1）、基质金属蛋白-9（MMP-9）的相关性及其临床价值。方法同期对103例初诊2型糖尿病患者（糖尿病组）和103例健康志愿者（对照组）的HbA1c水平及血清MCP-1和MMP-9进行检测和相关性分析。结果糖尿病组患者的HbA1c及血清MCP-1和MMP-9水平，均明显高于对照组，差异均有统计学意义（t分别=17.04、7.23、10.28，P均＜0.05）。糖尿病患者血清MCP-1和MMP-9均与HbA1c呈正相关性（r分别=0.75、0.74、P均＜0.05）。结论即使对于初诊2型糖尿病患者，也应全面筛查和评估有无发生糖尿病并发症和相关风险性；监测HbA1c也可间接反映患者体内免疫炎症反应的强度及并发症发生情况。