5-Phosphate pyridoxal (PPL) is the active coenzyme form of vitamin B6, acting as a coenzyme in a multitude of biochemical processes, therefore chitosan derivatives containing pyridoxal phosphate skeleton will provide an important material for the application of chitosan in the emerging biological function material. Chitosan phosphopyridoxal Schiff base derivative was synthesized by the condensation reaction of chitosan and 5-phosphate pyridoxal in an ionic liquid, 1-butyl-3-methylimidazolium chloride (BmimCl). The product was characterized by Fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR), XRD and TGA. The results showed that phosphopyridoxal group was successfully introduced onto the chitosan chain. It was found that degree of substitution of modified chitosan could reach 16.3%.
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