具有两亲性和温敏性的嵌段共聚物在选择性溶剂中能够自组装形成独特的微米级甚至纳米级有序结构，具有广泛的潜在应用。聚N-异丙基丙烯酰胺（PNIPAM）是一种典型的温敏性高分子材料，其分子链表现出独特的温敏行为，关于其修饰改性以及自组装行为的研究一直广受关注。以PNIPAM为基点介绍其嵌段共聚物的自组装行为，详细综述影响其行为的诸多因素如组成、分子量、外界刺激条件等，介绍其在生物医药、催化反应等方面的应用，并对其未来的发展方向进行了展望。%The amphiphilic and thermosensitive block copolymers can self-assemble and turn into special micron level or nanoscale morphologies in selective solvents, and they have extensive potential applications. Poly(N-isopropyl acrylamide) (PNIPAM) is a typical kind of thermal-sensitive macromolecular material. It can undergo a special“coil to globule”volume phase transition near the lower critical solution temperature in solution. The study of self-assembly of its block copolymers has been drawn great interests. In this paper, self-assembly of PNIPAM block copolymers is introduced. The influence of several aspects including composition, molecular weight, external stimulus conditions and so on is systematically reviewed. Some of its applications on biological medicine, catalysis reaction, etc. are also introduced. The direction of its future development is also forecasted.
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