目的 对临床分离的1 274株铜绿假单胞菌的来源分布及其耐药情况进行分析,以指导临床合理用药.方法 对2009年8月至2010年8月送检标本进行常规的分离培养,并用Vitek2 Compact和ATB Express系统进行病原学鉴定和测定其耐药性.结果 共分离到1 274株铜绿假单胞菌,其中从痰标本中分离到959株,占75.27%,各ICU病房共分离到777株,占61.00%.其对美罗培南的耐药性最低,为18.13%;其次对哌拉西林/他唑巴坦、头孢吡肟和阿米卡星的耐药率也较低,分别为18.35%、18.89%、19.94%.结论 铜绿假单胞菌易产生多重耐药性,必须加强耐药性监测,为临床提供最新的耐药性资料,以更好地控制铜绿假单胞菌感染.%Objective To analysis the distribution and drug sensitivity of Pseudomonas aeruginosa separated from the first affiliated hospital of Chongqing medical university between Aug. 2009 and Aug. 2010 to guide the clinical rational use of drugs. Methods Bacterial identification and minimal inhibitory concentration(MIC)determination were performed by VITEK2 Compact or ATB Express system. Data was analyzed by WHONET5. 5 software. Results 1 274 strains of Pseudomonas aeruginosa were isola ted. 959 strains were separated from sputum accounted for 75.28％ and 777 strains were isolated from the all intensive care units accounted for 61.00％. The meropenem against these Pseudomonas aeruginosa were most sensitive with the resistance rate of 18. 13％. Then,the resistance rates of pipercilin/tazobactam,cefepime and kanamycin were all less than 20.00％. Conclusion Pseudo monas aeruginosa is easy to produce multi resistance. We must strengthen resistance monitor to provide the latest resistance infor marion of Pseudomonas aeruginosa clinically so that Pseudomonas aeruginosa infection could be controlled better.
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