Objective To observe the curative effect and side effects of combined therapy of autologous bone marrow stem cell transplantation and splenectomy plus disconnection in decompensated liver cirrhosis. Methods 34 patients with decompensated liver cirrhosis(child-pugh C) from department of hepatobiliary surgery were collected, 17 patients as the test group underwent combined therapy of autologous bone marrow stem cell transplantation and splenectomy plus disconnection, 17 patients as the control group were treated by appendectomy and disconnection only. Then we compared the treatment result of two groups. Results AST, ALT, TBIL and abdominal circumference in test group after treatment reduced gradually, but WBC, PLT, PT, ALB and PA increased gradually. The result was better than the control one. It showed that the liver function of the patients in test group improved obviously. Conclusion The curative effect combined therapy of autologous bone marrow stem cell transplantation and splenectomy plus disconnection in decompensated liver cirrhosis is significant. It s one of the best treatment to liver cirrhosis.%目的 观察自体骨髓干细胞联合脾切除断流术治疗失代偿期肝硬化的疗效及不良反应.方法 选择肝胆外科失代偿期肝硬化(child-pugh C)患者34例,其中17例为治疗组,在一般治疗的基础上应用自体骨髓干细胞联合脾切除断流术治疗,另17例为对照组,仅行脾脏切除断流术.观察并比较两组的治疗结果.结果 术后干细胞治疗组天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、总胆红素(TBIL),腹围等指标逐渐降低;白细胞(WBC)、血小板(PLT)、凝血酶原时间(PT)、血清清蛋白(ALB)、前清蛋白(PA)逐渐升高,程度优于对照组,可以提示治疗组患者肝功能明显改善优于对照组.结论 自体骨髓干细胞联合脾切除断流术治疗失代偿期肝硬化疗效显著,应属目前最有效治疗肝硬化方法之一.
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