p53、C-myc 和 CerbB-2在甲状腺乳头状癌中的表达及临床意义

摘要

目的：探讨 p53、C-myc 和 CerbB-2在甲状腺乳头状癌患者中的表达情况及临床意义。方法免疫组织化学法检测45例甲状腺乳头状癌和45例结节性甲状腺肿组织标本 p53、C-myc 和 CerbB-2表达情况，分析其与患者临床病理特征的关系。结果 p53、C-myc 和 CerbB-2在甲状腺乳头状癌中阳性表达率均明显高于结节性甲状腺肿（P ＜0．01）。 p53和 C-myc 在甲状腺乳头状癌的表达与淋巴结转移有关（P＜0．05）；CerbB-2在甲状腺乳头状癌的表达与肿瘤大小、局部浸润、TNM 分期、分化程度和淋巴结转移有关（均 P＜0．05）。 p53、C-myc 和 CerbB-2阳性表达均是甲状腺乳头状癌患者淋巴结转移的独立危险因素。结论p53、C-myc 和 CerbB-2在甲状腺乳头状癌中呈高表达，并与淋巴结转移有关，对三者进行检测可成为甲状腺乳头状癌早期诊断的评价指标。%Objective To investigate the expression level and clinical significance of p53 ,C-myc and CerbB-2 in papillary thy-roid carcinoma patients .Methods The expression level of p53 ,C-myc and CerbB-2 were detected in 45 cases of papillary thyroid carcinoma tissue specimens and 45 cases of nodular goiter tissue specimens by using immunohistochemical staining .Their correla-tions with clinic pathological features in papillary thyroid carcinoma were analyzed further .Results The positive expression rates of p53 ,C-myc and CerbB-2 in the papillary thyroid carcinoma tissue specimens were significantly higher than that of the nodular goiter tissue specimens(all P< 0 .01) .The expression of C-myc and CerbB-2 significantly correlated with lymph node metastasis(P< 0 . 05) .The expression of CerbB-2 significantly correlated with tumor size ,local infiltration ,TNM stage ,differentiated degree and lymph node metastasis (all P< 0 .05) .p53 positive expression ,C-myc positive expression and CerbB-2 positive expression were the independent factors of cervical lymph node metastasis .Conclusion p53 ,C-myc and CerbB-2 were highly expressed in papillary thy-roid carcinoma and correlated with cervical lymph nody metastasis .The detection of p53 ,C-myc and CerbB-2 might be helpful for diagnosis of papillary thyroid carcinomas .