腮腺癌组织PAX2和PAX8表达联合预测其根治术后复发、转移的价值

摘要

Objective To investigate the value of parotid gland carcinoma tissue PAX2 and PAX8 expression for combined prediction of recurrence and metastasis after radical surgery.Methods Forty-six patients with parotid gland carcinoma treated by parotid gland joint neck radical operation served as the research subjects.The immunohistochemical method was applied to detect the PAX2 and PAX8 protein expression level in surgical removal parotid gland carcinoma tissues and tissues adjacent to carcinoma.Results The PAX2 and PAX8 protein positive expression rates of parotid gland carcinoma tissue were 76.09％ and 69.57％ respectively,which were higher than 26.09 ％ and 28.26 ％ in the tissue adjacent to carcinoma (P＜0.05).The local recurrence rate in the patients with parotid gland carcinoma radical operation and 3-year follow-up was 41.30％,and lymph node metastasis rate was 34.78％.Moreover the metastasis and recurrence rate in the patients with PAX2 protein positive expressing were higher than those in the patients with PAX2 negative expression,and the metastasis and recurrence rate in the patients with PAX8 protein positive expressionwere higher than those in the patients with PAX8 negative expression (P＜0.(05).The Logistic regression analysis results showed that parotid gland carcinoma tissue PAX2 and PAX8 expression levels had close correlation with the recurrence and metastasis after radical surgery were closely correlated (P＜0.05).Parotid gland carcinoma tissue PAX2 and PAX8 expression levels for predicting the post-operative recurrence and metastasis had good value,in which the value of PAX2 positive and PAX8 positive expression for predicting the recurrence and metastasis was optimal.Conclusion Parotid gland carcinoma tissue PAX2 and PAX8 expression levels are closely correlated with the prognosis situation such as recurrence and metastasis after radical surgery,moreover their combined detection has better value for predicting the prognosis,which can serve as the reference indicator for the prognosisassessment after radical operation of parotid gland carcinoma.%目的 探讨腮腺癌组织成对盒基因2(PAX2)和成对盒基因8(PAX8)表达联合预测其根治术后复发、转移的价值.方法 以行腮腺颈联合根治术治疗的腮腺癌患者46例为研究对象.采用免疫组织化学法检测其手术切除腮腺癌组织及癌旁组织中PAX2和PAX8蛋白表达水平.结果 腮腺癌组织PAX2和PAX8蛋白阳性表达率分别为76.09％和69.57％,均高于癌旁组织的26.09％和28.26％ (P＜0.05).腮腺癌根治术治疗患者随访3年的局部复发率为41.30％,淋巴结转移率为34.78％.且PAX2蛋白阳性表达患者的复发率和转移率均高于其阴性表达患者,PAX8蛋白阳性表达患者的复发率和转移率亦均高于其阴性表达患者(P＜0.05).Logistic回归分析结果显示,腮腺癌组织PAX2和PAX8表达水平与其根治术后复发、转移均密切相关(P＜0.05).腮腺癌组织PAX2和PAX8表达水平预测其术后复发、转移的价值良好,其中以PAX2阳性和PAX8阳性预测其术后复发、转移的价值最优.结论 腮腺癌组织PAX2和PAX8表达水平与其根治术后复发、转移等预后情况的密切相关且联合预测其预后的价值良好,联合检测腮腺癌组织PAX2和PAX8蛋白表达可作为腮腺癌根治术预后评估的参考指标.